In the nine years since it debuted, "It's Showtime" has grown its audience to become the number one show in its noontime slot not only with innovative and entertaining segments, but also with the natural, often hilarious, chemistry of its main hosts.

Vice Ganda and Anne Curtis, both original mainstays of "It's Showtime" since its 2009 premiere, had been acquaintances prior, but have evidently become close friends and "sisters" over the years, as the then-morning talent search evolved into ABS-CBN's flagship variety show.

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Their closeness have been evident in their co-hosting stints, past and present. Currently, they share the stage during the "Miss Q&A" and "Tawag ng Tanghalan" segements of the three-hour program.

As each episode unfolds live and without cuts (save for the taped ones ahead of long holidays), Vice Ganda and Curtis, along with other hosts, have an expansive room to play and experiment in in terms of banter and impromptu skits -- often producing laugh-out-loud results.

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Clips of these scenes uploaded on YouTube, unsurprisingly, have amassed over a million views each, with comments ranging from requests to pair the two in a movie, to thanking the show for relieving viewers' stress. "Sakit sa panga!" and "iyak-tawa" are examples of common responses.

In videos, here are 10 of Vice Ganda and Curtis' funniest moments on "It's Showtime," from the comedian throwing a fit over the actress' unabashed singing, to their imagined history as twin sisters: