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Rare is a more frustrating feeling than knowing you could have done something to save a loved one.

And in this heart-pinching interview on "Tonight With Boy Abunda" on Friday, Nadine Lustre bravely opened up about her deep regret over not spending more time with her late brother.

"If I had talked to him more or if he had opened up to me, baka in a way I could have changed what happened," she said, the note of sadness in her voice underlining just how raw her grief is.

Her brother died inside their family home last October.

Lustre said that one of the most important lessons she learned was to make her loved ones feel appreciated every single day.

"Kasi hindi mo alam kung hanggang kailan lang or kung gaano lang katagal magla-last iyang mga iyan sa iyo," she explained.

The actress also shared that she has learned to accept the death, reasoning that "what's meant to happen will happen."

Lustre was with her boyfriend, James Reid, for the interview.

Reid said that the painful incident had a profound effect on Lustre, noting that she became more open with her feelings.

"I think it's because she kept trying to be strong for her family, for everyone who's looking up to her," he pointed out. "She was really holding her emotions in and didn't want to let them go."

"And that was one of the things I tried to get out her --na it's OK to feel sad, it's OK to cry and let it out, it's natural, it's just human. I think after that, she really learned to open up and trust me with her emotions," he added.

As the interview aired, Lustre's fans took to Twitter to praise her for her strength in talking about her pain.

Courageous. Tough. Nadine, you've earned more respect from me. To not falter, stutter between words when asked about your brother's death.. it was apparent you still haven't moved on. But you stood your ground.

If it was me? I might have cried an ocean. Hats off. #JADINEtonight

— cRAYEzy (@JaDinedelions) January 19, 2018

I love you Tito Boy! That discussion of her brother's loss was just perfectly gentle and sincere. There were a few moments, I heard Nadine's voice break but with James beside her, she felt comfortable. I admit, it gave my heart a pinch & started to tear up. #JADINEtonight

— Aisa N. 💗 (@Stubborn_Luv) January 19, 2018

I was about to tear up when nadine was talking about his brother like MY BABY YOURE SO STRONG 😌😌#JADINEtonight

— ً (@hoelyjadine) January 19, 2018

I really admire Nadine speaking of his brother’s loss without breaking down and I admire James being there with her the whole time #JadineTonight

— KClaire R (@kclaire317) January 19, 2018

I really admire Nadine. Her brother's death is a very sensitive topic for her and she answered Tito Boy's question without shedding a tear. I love you Naddie!! 😍#JADINEtonight

— Vanaleigh Santos (@vanaleighdy) January 19, 2018