Veteran U.S. senator and war hero John McCain -- a towering figure in American politics for decades -- has stopped treatment for brain cancer, his family announced Friday, one year after the Republican went public with his diagnosis.
The announcement signals the beginning of the end of a tough battle with glioblastoma, an aggressive form of brain cancer -- and of a storied life that took him from a Hanoi prison to the doorstep of the White House.
"The progress of disease and the inexorable advance of age render their verdict," the 81-year-old senator's loved ones said in a statement.
"With his usual strength of will, he has now chosen to discontinue medical treatment."
McCain has spent more than three decades in the upper chamber of Congress, looming large in debates over war and peace and the moral direction of the nation.
The Navy fighter pilot spent years as a prisoner of war in Vietnam after being shot down while on a bombing mission over Hanoi.
He lost the 2008 presidential election to Barack Obama, and was pilloried for selecting controversial Alaska politician Sarah Palin as his running mate.
With no more elections to run, since 2016, he has been a rare and outspoken Republican critic of President Donald Trump.
Known for his combustive temper, he has accused the 45th president of "naivete", "egotism" and of sympathizing with autocrats.
Following Trump's recent summit with Russian President Vladimir Putin, McCain caustically described the US leader's behavior as "one of the most disgraceful performances by an American president in memory."
- 'Strength to carry on' -
McCain has not been on the Senate floor in months, remaining at his Arizona home for treatment. Glioblastoma is the same form of brain cancer that took the life of another Senate giant, Democrat Ted Kennedy, in 2009.
"I love my husband with all of my heart. God bless everyone who has cared for my husband along this journey," his wife Cindy said.
His daughter Meghan thanked the public for an outpouring of support.
"My family is deeply appreciative of all the love and generosity you have shown us during this past year," she tweeted.
"Thank you for all your continued support and prayers. We could not have made it this far without you - you've given us strength to carry on."
Republican Senate Majority Leader Mitch McConnell said he was "very sad to hear this morning’s update from the family of our dear friend."
"We are so fortunate to call him our friend and colleague. John, Cindy, and the entire McCain family are in our prayers at this incredibly difficult hour."