ST. LOUIS, Missouri - Quarterback Sam Bradford threw two touchdown passes and got plenty of support from his defense as the St. Louis Rams knocked off the previously undefeated Arizona Cardinals 17-3 Thursday.
Bradford completed just seven-of-21 passes for 141 yards with an interception for the Rams, who have won their last two National Football League games to push their record over the .500 mark for the first time in almost six years.
Robert Quinn recorded three sacks to lead a stifling St. Louis defence that racked up nine sacks of Cardinals quarterback Kevin Kolb. James Laurinaitis, Cortland Finnegan, Jo-Lonn Dunbar, Bradley Fletcher, Chris Long and Jermell Cudjo had one sack each for the Rams.
Runningback Steven Jackson rushed for 76 yards on 18 carries, while Chris Givens and Lance Kendricks each caught a touchdown for St. Louis.
Kolb completed 28-of-50 passes for 289 yards for Arizona, who suffered their first loss of the season after four straight wins.
Arizona receiver Larry Fitzgerald had a game-high eight catches for 92 yards.
In key games this weekend, New Orleans quarterback Drew Brees needs just one more touchdown pass to surpass hall of famer Johnny Unitas and set an NFL record with 48 consecutive games with at least one touchdown pass.
Three-time most valuable player Unitas finished his career with 47. The 0-4 Saints are hosting San Diego.
The Pittsburgh Steelers will be well rested when they host the Philadelphia Eagles as the Steelers are coming off a bye week. They will also have safety Troy Polamalu, linebacker James Harrison and runningback Rashard Mendenhall returning to the lineup.
Peyton Manning's Denver Broncos travel to New England to face quarterback Tom Brady and the Patriots. The two superstar quarterbacks have met 12 times previously with Brady winning eight.
This is just the second time in league history the two starting quarterbacks have more than 125 career regular season victories. Manning has 143 while Brady has 126.
On Monday night, the undefeated Houston Texans travel to the New York Jets who will be without one of their big offensive weapons.
Wide receiver Santonio Holmes will miss the rest of the season with a foot injury so the Jets went out and signed Jason Hill to replace him.
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