Fire struck the 43-storey Discovery Suites in Ortigas Center in Pasig Sunday evening, forcing residents and guests of the posh hotel out to the streets.
The fire started at 6:45 pm at the fourth floor of the hotel, which is located along ADB Avenue.
Residents and guests, mostly foreigners, were forced to evacuate the hotel.
Most of the foreign guests left their belongings, except for their passports, inside the hotel.
Firefighters have already broken the windows of the fourth floor units to force thick smoke out of the building.
Nobody was reported killed or injured in the incident.
Motorists are advised to avoid the area which has been closed to traffic.